State space mixed models for longitudinal obsservations with binary and binomial responses

We propose a new class of state space models for longitudinal discrete response data where the observation equation is specified in an additive form involving both deterministic and random linear predictors. These models allow us to explicitly address the effects of trend, seaonal or other time-varying covariates while preserving the power of state space models in modeling serial dependence in the data. We develop a Markov Chain Monte Carlo algorithm to carry out statistical inferene for models with binary and binomial responses, in which we invoke de Jong and Shephard's (1995) simulaton smoother to establish an efficent sampling procedure for the state variables. To quantify and control the sensitivity of posteriors on the priors of variance parameters, we add a signal-to-noise ratio type parmeter in the specification of these priors. Finally, we ilustrate the applicability of the proposed state space mixed models for longitudinal binomial response data in both simulation studies and data examples

Time-Deformation Modeling Of Stock Returns Directed By Duration Processes

This paper presents a new class of time-deformation (or stochastic volatility) models for stock returns sampled in transaction time and directed by a generalized duration process. Stochastic volatility in this model is driven by an observed duration process and a latent autoregressive process. Parameter estimation in the model is carried out by using the method of simulated moments (MSM) due to its analytical feasibility and numerical stability for the proposed model. Simulations are conducted to validate the choices of the moments used in the formulation of the MSM. Both the simulation and empirical results obtained in this paper indicate that this approach works well for the proposed model. The main empirical findings for the IBM transaction return data can be summarized as follows: (i) the return distribution conditional on the duration process is not Gaussian, even though the duration process itself can marginally function as a directing process; (ii) the return process is highly leveraged; (iii) a longer trade duration tends to be associated with a higher return volatility; and (iv) the proposed model is capable of reproducing return whose marginal density function is close to that of the empirical return.Duration process; Ergodicity; Method of simulated moments; Return process; Stationarity.

Efficient Estimation of the Partly Linear Additive Hazards Model with Current Status Data

This paper focuses on efficient estimation, optimal rates of convergence and effective algorithms in the partly linear additive hazards regression model with current status data. We use polynomial splines to estimate both cumulative baseline hazard function with monotonicity constraint and nonparametric regression functions with no such constraint. We propose a simultaneous sieve maximum likelihood estimation for regression parameters and nuisance parameters and show that the resultant estimator of regression parameter vector is asymptotically normal and achieves the semiparametric information bound. In addition, we show that rates of convergence for the estimators of nonparametric functions are optimal. We implement the proposed estimation through a backfitting algorithm on generalized linear models. We conduct simulation studies to examine the finite‐sample performance of the proposed estimation method and present an analysis of renal function recovery data for illustration.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110752/1/sjos12108.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/110752/2/sjos12108-sup-0001-supinfo.pd

fastMI: a fast and consistent copula-based estimator of mutual information

As a fundamental concept in information theory, mutual information (MI) has been commonly applied to quantify association between random variables. Most existing estimators of MI have unstable statistical performance since they involve parameter tuning. We develop a consistent and powerful estimator, called fastMI, that does not incur any parameter tuning. Based on a copula formulation, fastMI estimates MI by leveraging Fast Fourier transform-based estimation of the underlying density. Extensive simulation studies reveal that fastMI outperforms state-of-the-art estimators with improved estimation accuracy and reduced run time for large data sets. fastMI provides a powerful test for independence that exhibits satisfactory type I error control. Anticipating that it will be a powerful tool in estimating mutual information in a broad range of data, we develop an R package fastMI for broader dissemination

Adaptive Bootstrap Tests for Composite Null Hypotheses in the Mediation Pathway Analysis

Mediation analysis aims to assess if, and how, a certain exposure influences an outcome of interest through intermediate variables. This problem has recently gained a surge of attention due to the tremendous need for such analyses in scientific fields. Testing for the mediation effect is greatly challenged by the fact that the underlying null hypothesis (i.e. the absence of mediation effects) is composite. Most existing mediation tests are overly conservative and thus underpowered. To overcome this significant methodological hurdle, we develop an adaptive bootstrap testing framework that can accommodate different types of composite null hypotheses in the mediation pathway analysis. Applied to the product of coefficients (PoC) test and the joint significance (JS) test, our adaptive testing procedures provide type I error control under the composite null, resulting in much improved statistical power compared to existing tests. Both theoretical properties and numerical examples of the proposed methodology are discussed

Fused lasso with the adaptation of parameter ordering in combining multiple studies with repeated measurements

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135531/1/biom12496.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/135531/2/biom12496_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/135531/3/biom12496-sup-0001-SuppData.pd